Allosteric Catch Bond Properties of the FimH Adhesin from Salmonella enterica Serovar Typhimurium
نویسندگان
چکیده
منابع مشابه
Catch-bond mechanism of the bacterial adhesin FimH.
Ligand-receptor interactions that are reinforced by mechanical stress, so-called catch-bonds, play a major role in cell-cell adhesion. They critically contribute to widespread urinary tract infections by pathogenic Escherichia coli strains. These pathogens attach to host epithelia via the adhesin FimH, a two-domain protein at the tip of type I pili recognizing terminal mannoses on epithelial gl...
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Salmonella enterica serovar Typhimurium and S.enterica serovar Enteritidis are the most frequently isolated serovars from food-borne diseases throughout the world. According to their antigenic profiles, salmonella shows different disease syndromes and host specificities. It is necessary and important to discriminate salmonella serovars from each other in order to ensure that each pathogen and i...
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Bacterial virulence mechanisms stem from the selective pressure of host environment and Salmonella enterica serovar Typhimurium (S. typhimurium) is an ideal example of this [1]. S. typhimurium causes self-limiting gastroenteritis and poses serious health problem in the regions of unhygienic conditions. Adhesin mediated attachment of enteric pathogens to host intestinal mucosa is an important ea...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.237511